宠物过敏的儿童哮喘持续更久

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宠物过敏的儿童哮喘持续更久。根据一项新的研究表明:虽然许多哮喘儿童,随着年龄增长不再哮喘,但严重哮喘或对毛茸茸的动物过敏可能提示哮喘将持续到成年。

研究人员在1996年纳入248瑞典七八岁哮喘儿童,父母填写问卷,每年随访,直到孩子们满19岁。

十几岁的时候,205名孩子们仍未退出研究,其中43人(五分之一)病情缓解,定义为三年或三年以上无喘息或使用药物。

19岁时,84名孩子有持续性哮喘,78例周期性哮喘。

总体而言,男性和无严重过敏或动物过敏,哮喘缓解的几率增加一倍。

研究结果发表在Pediatrics杂志。

Remission and Persistence of Asthma Followed From 7 to 19 Years of Age

BACKGROUND AND OBJECTIVE:

To date, a limited number of population-based studies have prospectively evaluated the remission of childhood asthma. This work was intended to study the remission and persistence of childhood asthma and related factors.

METHODS:

In 1996, a questionnaire was distributed to the parents of all children aged 7 to 8 years in 3 municipalities in northern Sweden, and 3430 (97%) participated. After a validation study, 248 children were identified as having asthma; these children were reassessed annually until age 19 years when 205 (83%) remained. During the follow-up period lung function, bronchial challenge testing, and skin prick tests were performed. Remission was defined as no use of asthma medication and no wheeze during the past 12 months as reported at endpoint and in the 2 annual surveys preceding endpoint (ie, for ≥3 years).

RESULTS:

At age 19 years, 21% were in remission, 38% had periodic asthma, and 41% persistent asthma. Remission was more common among boys. Sensitization to furred animals and a more severe asthma (asthma score ≥2) at age 7 to 8 years were both inversely associated with remission, odds ratio 0.14 (95% confidence interval 0.04–0.55) and 0.19 (0.07–0.54), respectively. Among children with these 2 characteristics, 82% had persistent asthma during adolescence. Asthma heredity, damp housing, rural living, and smoking were not associated with remission.

CONCLUSIONS:

The probability of remission of childhood asthma from age 7- to 8-years to age 19 years was largely determined by sensitization status, particularly sensitization to animals, asthma severity, and female gender, factors all inversely related to remission.

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